Shuzo Sakata

The paper identifies distributed neural ensembles across sleep stages in mice, revealing state-dependent firing patterns and temporal organization across multiple timescales.

The paper introduces a multi-fiber array-based photometry system for monitoring neural activity across multiple brain regions in mice, demonstrating its utility in studying state-dependent GABAergic dynamics.

This paper introduces a depth-resolved fiber photometry method to monitor amyloid plaque signals in freely behaving Alzheimer's disease mice, showing depth-specific fluorescent signal increases in diseased mice.

This study shows that experience-dependent increases in hippocampal sharp-wave ripples are disrupted in 5xFAD Alzheimer's disease mice, suggesting non-cholinergic pathological changes.

This study shows that overproduction of cortical superficial neurons in mice impairs auditory processing and behavior in adulthood.

SaLSa classifies mouse behavioral syllables using semi-automatic labeling and LSTM, achieving over 97% accuracy and revealing age-related hyperactivity in Alzheimer's mice.

This study investigates P-waves during NREM sleep, showing they share short-term dynamics with REM sleep P-waves but differ in longer-term cholinergic dynamics and hippocampal coupling.

This study shows that astrocyte Ca2+ levels change with sleep/wakefulness states and vary across brain regions in mice.

This study shows that optogenetic activation of basal forebrain parvalbumin neurons increases amyloid burden in Alzheimer's mice, suggesting bidirectional effects of gamma oscillations on disease pathology.

The paper identifies three distinct inhibitory input sources to the lateral habenula from local and distant neurons, revealing its neuronal diversity.

This paper combines electrophysiological recording and fiber photometry to simultaneously monitor sub-second neural activity and cell-type-specific calcium transients in freely behaving mice.

This study investigates state-dependent dynamics of pontine ensembles and their interactions with the cortex across sleep states in mice, revealing distinct functional roles of sleep.

The paper uses a simplified network model to show how pathway-specific synaptic manipulations affect sleep-wake dynamics, revealing pathway-dependent regulation of sleep states.

The paper identifies two alternating neural populations in synchronized states using ICA, one associated with slow cortical activity and the other with theta oscillations from subcortical regions.

This paper develops Cre-dependent optogenetic mice on CBA/Ca background to study hearing mechanisms without early age-related hearing loss.