Author

Richard Southworth

King's College LondonORCID 0000-0002-7904-8335Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:rat· 1

Frequent Co-Authors

Thomas R. EykyniD· 3 shared Edward C. T. WatersiD· 2 shared Friedrich BaarkiD· 2 shared Abbe Harper CrawfordiD· 1 shared Adam JonesiD· 1 shared Aidan M. MichaelsiD· 1 shared Alain OregioniiD· 1 shared Alex RigbyiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Thomas R. EykynORCID

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3 papers

Recent·Most cited

Mitochondrial Optic Atrophy (OPA)1 expression regulates the injury response to neonatal hypoxia-ischaemia.

Claire J. M. Curel, Adam Jones, Abbe Harper Crawford, Ane Goikolea-Vives, Gwladys Chabrier, Gabriela Gil, Alain Oregioni, Richard Southworth, Thomas R. Eykyn, Helen B. Stolp, Irene Nobeli, Claire Thornton

This study shows that OPA1 expression affects mitochondrial function and DNA content in neonatal hypoxia-ischaemia, with OPA1 loss leading to mitochondrial fragmentation and increased brain injury.

bioRxiv · Jul 10, 2026 · PreprintNeuroscience

Sarcolemmal and mitochondrial membrane potentials measured ex vivo and in vivo in the heart by pharmacokinetic modelling of sestamibi

Edward C. T. Waters, Friedrich Baark, Matthew R. Orton, Michael J. Shattock, Richard Southworth, Thomas R. Eykyn

The paper estimates sarcolemmal and mitochondrial membrane potentials in the heart using pharmacokinetic modeling of sestamibi data from ex vivo and in vivo experiments.

The Journal of Physiology · Mar 16, 2026Peer-reviewedBiochemistry

Perfusion-Independent Tissue Hypoxia in Cardiac Hypertrophy in Mice Measured by 64Cu-CTS PET Imaging

Friedrich Baark, Aidan M. Michaels, Edward C. T. Waters, Alex Rigby, Jana Kim, Zilin Yu, Victoria R. Pell, James Clark, Philip J. Blower, Thomas R. Eykyn, Richard Southworth

This study shows that 64Cu-CTS PET detects hypoxia in hypertrophic mouse hearts independent of perfusion, linking it to structural changes and metabolic shifts.

bioRxiv · Apr 22, 2024 · PreprintBioengineering