Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8
Kenea C Udobi, Amanda N. Kokenge, Emily R. Hautman, Gabriela Ullio, Julie Coëne, Michael T. Williams, Charles V. Vorhees, Aloïse M Mabondzo, Matthew R. Skelton
This study creates brain-specific Slc6a8 knockout mice and shows that reduced cerebral creatine causes cognitive deficits without affecting swim speed, unlike ubiquitous knockout mice.
Genes Brain & Behavior · Jan 31, 2018Peer-reviewedNeuroscience