Author

Aloïse M Mabondzo

Commissariat à l'Énergie Atomique et aux Énergies AlternativesORCID 0000-0002-0627-8949Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Matthew R. SkeltoniD· 3 shared Anne-Cécile Guyot· 2 shared Jean ArmengaudiD· 2 shared Léa Broca-Brisson· 2 shared Narciso CostaiD· 2 shared Rania HaratiiD· 2 shared Rifat HamoudiiD· 2 shared Ágota ApátiiD· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Matthew R. SkeltonORCID

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3 papers

Recent·Most cited

Deciphering Neuronal Deficit and Protein Profile Changes in Human Brain Organoids from Patients with Creatine Transporter Deficiency

Léa Broca-Brisson, Rania Harati, Clémence Disdier, Orsolya Mózner, Romane Gaston-Breton, Auriane Maïza, Narciso Costa, Anne-Cécile Guyot, Balázs Sarkadi, Ágota Apáti, Matthew R. Skelton, Lucie Madrange, Frank Yates, Jean Armengaud, Rifat Hamoudi, Aloïse M Mabondzo

This study uses human brain organoids to show that restoring SLC6A8 function in CTD patients normalizes protein expression and creatine uptake, suggesting potential therapeutic targets for CTD.

bioRxiv · Jun 1, 2023 · PreprintNeuroscience

Dodecyl Creatine Ester Improves Cognitive Function and Identifies Drivers of Creatine Deficiency.

Aloïse M Mabondzo, Rania Harati, Léa Broca-Brisson, Anne-Cécile Guyot, Narciso Costa, Francesco Cacciante, Elena Putignano, Laura Baroncelli, Matthew R. Skelton, Cathy Saab, Emmanuelle M.-D Martini, Henri Bénech, Thomas Joudinaud, Jean‐Charles Gaillard, Jean Armengaud, Rifat Hamoudi

The paper identifies 14 biomarkers associated with cognitive improvement in a Slc6a8 knockout mouse model treated with DCE, linking them to proteins involved in CTD pathogenesis.

bioRxiv · Nov 3, 2022 · PreprintNeuroscience

Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8

Kenea C Udobi, Amanda N. Kokenge, Emily R. Hautman, Gabriela Ullio, Julie Coëne, Michael T. Williams, Charles V. Vorhees, Aloïse M Mabondzo, Matthew R. Skelton

This study creates brain-specific Slc6a8 knockout mice and shows that reduced cerebral creatine causes cognitive deficits without affecting swim speed, unlike ubiquitous knockout mice.

Genes Brain & Behavior · Jan 31, 2018Peer-reviewedNeuroscience