Michael T. Williams

Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice

This study shows that genetic activation of ERK2 in mice models key neurodevelopmental features of Rasopathy syndromes, including cognitive impairments and facial dysmorphology.

Latrophilin-3 conditional knockout in tyrosine hydroxylase neurons (Lphn3-Th-Cre) compared with Lphn3 global KO rats: Role of Lphn3 in tyrosine hydroxylase neurons on cognitive and behavioral effects of this ADHD susceptibility gene

This study compares global and conditional Lphn3 knockout rats to assess the role of Lphn3 in tyrosine hydroxylase neurons on ADHD-related behaviors and neuroplasticity.

Prenatal psychosocial stress-induced behavioral and neuroendocrine abnormalities are associated with sex-specific alterations in synaptic transmission and differentially modulated by maternal environment

This study shows prenatal stress causes sex-specific behavioral and neuroendocrine issues in mice, with maternal care reversing some effects.

Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8

This study creates brain-specific Slc6a8 knockout mice and shows that reduced cerebral creatine causes cognitive deficits without affecting swim speed, unlike ubiquitous knockout mice.