Generative AI designs functional thiolation domains for reprogramming non-ribosomal peptide synthetases
Emre Fatih Bülbül, Seounggun Bang, Kevin George, Gabriele Bianchi, Prateek Raj, Seonyong Chung, Vincent Pauline, Ramon Hochstrasser, Hannah A. Minas, Walid A. M. Elgaher, Andreas M. Kany, Anna K. H. Hirsch, Steven Schmitt, Dirk W. Heinz, Olga V. Kalinina, , Kenan A. J. Bozhüyük
This paper uses generative AI to design functional thiolation domains for reprogramming NRPSs, improving product formation and stability.
bioRxiv · Mar 4, 2026 · PreprintSynthetic Biology