Anna K. H. Hirsch

This paper discovers three new nanomolar inhibitors of LasB by combining generative design, free energy calculations, and experimental validation.

This study identifies tracheal tuft cells as sources of leukotrienes that promote antibacterial immune responses by detecting bacterial ATP via Trpm5.

This paper uses generative AI to design functional thiolation domains for reprogramming NRPSs, improving product formation and stability.

The paper investigates IspE kinase homologs from pathogenic bacteria, identifies structural differences affecting inhibitor binding, and highlights a hydrophobic pocket critical for inhibitor specificity in Acinetobacter baumannii.

The paper presents high-resolution crystal structures of DXPS from Pseudomonas aeruginosa and Klebsiella pneumoniae in different forms, revealing conformational changes upon cofactor binding and providing insights for drug design.