Andreas M. Kany

This paper discovers three new nanomolar inhibitors of LasB by combining generative design, free energy calculations, and experimental validation.

This study identifies tracheal tuft cells as sources of leukotrienes that promote antibacterial immune responses by detecting bacterial ATP via Trpm5.

This study identifies nitroxoline's antibacterial mechanism as pathogen-driven reactivation of its metabolites through iron deprivation in uropathogens.

This study isolates and characterizes two new compounds from myxobacteria, elucidates their structures, and evaluates their antimicrobial activity against Gram-positive bacteria.

This paper uses generative AI to design functional thiolation domains for reprogramming NRPSs, improving product formation and stability.

This study profiles cystobactamids' off-target effects in eukaryotes, showing safety, superoxide reduction, and SCARB1 inhibition with therapeutic potential.

The paper develops a thermo-amplifier circuit in probiotic E. coli to control the release of darobactin, a peptide antibiotic, at 40°C while maintaining low leakiness at 37°C.