ATXN2L primarily interacts with NUFIP2, the absence of ATXN2L results in NUFIP2 depletion, and the ATXN2-polyQ expansion triggers NUFIP2 accumulation
Jana Key, Luis Enrique Almaguer-Mederos, Arvind Reddy Kandi, Nesli-Ece Şen, Suzana Gispert, Gabriele Koepf, David Meierhofer, Georg W. J. Auburger
This study identifies ATXN2L interactors and shows that its absence leads to NUFIP2 depletion, while ATXN2-polyQ expansion causes NUFIP2 accumulation.
Neurobiology of Disease · Apr 11, 2025Peer-reviewedMolecular Biology