Nesli-Ece Şen

Limited proteolysis-coupled mass spectrometry captures proteome-wide protein structural alterations and biomolecular condensation in living cells

The paper introduces in-cell LiP-MS to study protein structural changes and biomolecular condensates in live human cells, revealing structural alterations under stress and validating them with microscopy.

ATXN2 polyglutamine expansion impairs QKI-dependent alternative splicing and oligodendrocyte maintenance

This study shows that ATXN2 polyglutamine expansion impairs QKI-dependent alternative splicing and oligodendrocyte maintenance in a mouse model of SCA2.

ATXN2L primarily interacts with NUFIP2, the absence of ATXN2L results in NUFIP2 depletion, and the ATXN2-polyQ expansion triggers NUFIP2 accumulation

This study identifies ATXN2L interactors and shows that its absence leads to NUFIP2 depletion, while ATXN2-polyQ expansion causes NUFIP2 accumulation.

Spinal cord phosphoproteome of a SCA2/ALS13 mouse model reveals alteration of ATXN2-N-term SH3-actin interactome and of autophagy via WNK1-MYO6-OPTN-SQSTM1

The paper analyzes the phosphoproteome and interactome of a SCA2/ALS13 mouse model to identify altered signaling and protein interactions linked to neurodegeneration.

Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression

This study examines an SCA2 mouse model to identify molecular mechanisms of spinal cord pathology, finding progressive TDP43 aggregation and cholesterol biosynthesis suppression.

Atxn2-CAG100-knock-in affects mouse lifespan and vestibulo-cerebellar function via neural disconnection

This paper describes a novel SCA2 mouse model with CAG100 expansion in Atxn2, showing reduced lifespan and vestibulo-cerebellar dysfunction due to axon-myelin disconnection.