David Meierhofer

The paper introduces MEMBRYO, a method for continuous SILAC proteomics in live embryos, revealing post-transcriptional regulation during neurogenesis.

This study uses deep learning and functional genomics to show that MEIS2 and TWIST1 co-regulation, along with changes in regulatory regions of PBX1, underlie bat forelimb specialization.

The paper shows that LPS priming enhances TLR7-driven Myddosome assembly in macrophages, linking microbial exposure to immune adaptation and autoimmunity risk.

This study shows that ATXN2 polyglutamine expansion impairs QKI-dependent alternative splicing and oligodendrocyte maintenance in a mouse model of SCA2.

The paper identifies SERPINB1 as a potential biomarker for SCA2 progression through multi-omics analysis in mice and validation in human patients.

This study identifies ATXN2L interactors and shows that its absence leads to NUFIP2 depletion, while ATXN2-polyQ expansion causes NUFIP2 accumulation.

This study shows that mutant Huntingtin causes neurodevelopmental issues in human brain organoids by disrupting CHCHD2, leading to mitochondrial and metabolic problems.

The paper shows that Ire1α regulates mRNA translation rates, which control the identity and polarity of upper layer cortical neurons through eIF4A1 and eEF-2.

This study shows that N4-acetylcytidine (ac4C) on mRNA promotes localization of transcripts and proteins to stress granules, regulating translation and stress response.

The paper identifies and characterizes LNCSOX17, a lncRNA essential for human endoderm formation, showing its role in regulating transcriptome and differentiation.

The paper shows hypoxia induces an early primitive streak signature in ES cells, enhancing gastruloid elongation and lineage representation through Hif1-mediated transcriptional changes.

The paper identifies lipid metabolism as a key factor in developmental pausing, showing that enhancing fatty acid oxidation extends embryo survival during mTOR inhibition.

The paper identifies NOP58 as a reader and SIRT7 as an eraser of the RNA acetylation ac4C, showing SIRT7 can deacetylate RNA in vitro and affecting snoRNA function and pre-rRNA processing.

This study shows SURF1 mutations impair human neurogenesis by generating patient-derived iPS cells and demonstrating defects in neuronal differentiation and bioenergetics.

This study identifies SON and SRRM2 as the core components of nuclear speckles by demonstrating that their combined depletion leads to near-complete dissolution of these structures.

This study shows that Nf1 is required for postnatal muscle growth and metabolic homeostasis, with loss of Nf1 causing muscle atrophy and metabolic changes.

This paper describes a novel SCA2 mouse model with CAG100 expansion in Atxn2, showing reduced lifespan and vestibulo-cerebellar dysfunction due to axon-myelin disconnection.