STING agonists in combination with epigenetic drugs potentiate ZNFX1-driven inflammatory necroptosis in TP53-mutated AML
Kaushlendra K. Tripathi, Lora Stojanovic, Zahra Gohari, Mostafa Abdelrheem, Gabriella Santos, Aviva Tyler, Brandon Cooper, Rena G. Lapidus, Darren J. Perkins, Alonso Heredia, Kenneth P. Nephew, Stephen B. Baylin, Michael J. Topper, Maria R. Baer, Feyruz Virgilia Rassool
This paper shows that STING agonists combined with epigenetic drugs enhance necroptosis in TP53-mutated AML by activating STING and upregulating interferon-related genes.
bioRxiv · Jul 28, 2026 · PreprintCancer Biology