PhysiologyJCI InsightPeer-reviewed
Macrophage-specific lipid nanoparticle therapy blocks the lungs mechanosensitive immunity due to macrophage-epithelial interactions
Liberty Mthunzi, Mohammad Naimul Islam, Galina A. Gusarova…·Jahar Bhattacharya
The paper shows that macrophage-specific lipid nanoparticle therapy blocks lung mechanosensitive immunity by inhibiting Ca2+ responses and TNF secretion in alveolar macrophages.