The cytoskeleton as a smart composite material: A unified pathway linking microtubules, myosin-II filaments and integrin adhesions
Nisha Bte Mohd Rafiq, Yukako Nishimura, Sergey V. Plotnikov, Visalatchi Thiagarajan, Zhen Zhang, Meenubharathi Natarajan, Shidong Shi, Virgile Viasnoff, Gareth E. Jones, Pakorn Kanchanawong, Alexander D. Bershadsky
This paper identifies KANK proteins as mediators linking microtubules to integrin adhesions, showing how microtubule disconnection triggers myosin-IIA filament assembly and remodeling of focal adhesions and podosomes.
bioRxiv · Jul 17, 2018 · PreprintCell Biology