Pakorn Kanchanawong

This study investigates how senescence alters the spatio-temporal dynamics of the nuclear lamina at the single-molecule level in human RPE cells.

The paper uses AI-assisted imaging and gene silencing to identify key proteins regulating epithelial tissue mechanics and their roles in cancer.

This study shows that progerin-induced senescent cells are eliminated by normal cells through mechanical competition and JNK/p38-MAPK pathways, while p16-induced senescent cells resist elimination.

This study identifies fibrillar adhesions as the primary integrin complexes that respond to matrix topography, forming independently of focal adhesions.

This study identifies β-catenin's role in regulating planar spindle orientation through Afadin cortical recruitment, ensuring symmetric epithelial cell division.

This paper introduces SiLM, a chip-based 3D single-molecule localization microscopy method that achieves high axial precision with a single-objective lens, comparable to 4Pi methods.

This study shows that nanoclusters of integrins organize phosphorylated FAK nanoclusters in focal adhesions, which are required for mechanosignalling and disassemble in response to inactivation signals.

This paper introduces a single-construct optogenetic tool to control talin dimerization, enabling precise manipulation of mechanotransduction in integrin-based adhesions.

This study identifies a GPCR signaling pathway in astrocytes that regulates F-actin remodeling and NSC reactivation through Mrtf nuclear translocation.

The paper shows that integrin nanoclusters self-organize within focal adhesions at an optimal distance to enable mechanotransduction, with cytoplasmic factors like talin and FHOD1 playing key roles.

ShareLoc provides an open platform for sharing and reanalyzing SMLM data to enhance image reconstruction through deep learning.

This paper identifies KANK proteins as mediators linking microtubules to integrin adhesions, showing how microtubule disconnection triggers myosin-IIA filament assembly and remodeling of focal adhesions and podosomes.

This study identifies actomyosin contractility as a mechanism driving bile regurgitation in obstructive cholestasis by forming vesicles that relieve biliary pressure.