Fibrillar adhesions are the primary integrin complexes shaped by matrix topography
Aaron J. Farrugia, Shao‐Zhen Lin, Yee Jun Yuen, Srinivas Sheshagiri Prabhu, Yilin Wang, Mui Hoon Nai, Sebastian Foo, Hamizah Ahmad Cognart, Chwee Teck Lim, Gianluca Grenci, Boon Chuan Low, Pakorn Kanchanawong, Jean-François Rupprecht, Jacques Prost, Alexander D. Bershadsky
This study identifies fibrillar adhesions as the primary integrin complexes that respond to matrix topography, forming independently of focal adhesions.
bioRxiv · Nov 26, 2025 · PreprintCell Biology