Cryo-EM Reveals Regulatory Mechanisms Governing Substrate Selection and Activation of Human LONP1
Jeffrey T. Mindrebo, Lauren Alexandrescu, Jennifer R. Baker, Garrett Wang, Gabriel C. Lander
This study uses cryo-EM to identify a novel intermediate state of LONP1 that regulates substrate selection and activation, providing insights into its role in mitochondrial proteostasis.
bioRxiv · Sep 5, 2025 · PreprintMolecular Biology