Author

Lauren Alexandrescu

Scripps Research InstituteORCID 0000-0003-0894-333XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

Gabriel C. LanderiD· 2 shared Garrett Wang· 1 shared Jeffrey T. MindreboiD· 1 shared Jennifer R. BakeriD· 1 shared William LessiniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

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5 top collaborators · 7 mutual co-author links

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2 shared papersMolecular Biology

Gabriel C. LanderORCID

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2 papers

Recent·Most cited

Molecular BiologyIUCrJPeer-reviewedOct 21, 2025

Mix-it-up: Accessible time-resolved cryo-EM on the millisecond timescale

Lauren Alexandrescu, William Lessin, Gabriel C. Lander

The paper introduces Mix-it-up, a method for rapid on-grid mixing and vitrification in cryo-EM to capture fast biochemical processes, demonstrating its effectiveness with high-resolution structural analysis.

3 citations

electronic health recordsexperimental assay

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Molecular BiologybioRxivPreprintSep 5, 2025

Cryo-EM Reveals Regulatory Mechanisms Governing Substrate Selection and Activation of Human LONP1

Jeffrey T. Mindrebo, Lauren Alexandrescu, Jennifer R. Baker…·Gabriel C. Lander

This study uses cryo-EM to identify a novel intermediate state of LONP1 that regulates substrate selection and activation, providing insights into its role in mitochondrial proteostasis.

DOI 10.1101/2025.09.05.674599

humanexperimental assay

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