Jeffrey T. Mindrebo

This study shows that IXA4 inhibits SLC33A1, causing ER hyperoxidation and activating IRE1/XBP1s signaling, which reduces viability of KEAP1-deficient lung cancer cells.

This study uses cryo-EM to identify a novel intermediate state of LONP1 that regulates substrate selection and activation, providing insights into its role in mitochondrial proteostasis.

This study redefines the hand-over-hand translocation mechanism of LONP1 using cryo-EM structures and biochemical assays, showing substrate binding regulates activity and ADP-bound ATPases can support translocation.

This study determines the cryo-EM structures of human LONP1 to elucidate the molecular mechanism of its proteolytic activation and regulation.