R-pyocin-mediated selection restores aminoglycoside sensitivity in a pan-drug resistant Pseudomonas aeruginosa isolate
Isaac Estrada, Davina Campbell, Garrett Welch, Parker Smith, Joanna B. Goldberg, Kendra P. Rumbaugh, Stephen P. Diggle
This paper shows that R-pyocin selective pressure can induce chromosomal deletions in Pseudomonas aeruginosa, leading to loss of multidrug resistance and restoration of aminoglycoside sensitivity.
bioRxiv · Aug 6, 2026 · PreprintMicrobiology