Joanna B. Goldberg

This study shows that culturing Staphylococcus aureus in Synthetic Cystic Fibrosis Medium 2 increases lung colonization and inflammation in a murine pneumonia model compared to standard agar plates.

This paper shows that R-pyocin selective pressure can induce chromosomal deletions in Pseudomonas aeruginosa, leading to loss of multidrug resistance and restoration of aminoglycoside sensitivity.

This study compares single colony and pooled colony isolates of Staphylococcus aureus from cystic fibrosis patients to reveal hidden intraspecific diversity in chronic infections.

This paper investigates how temperature and growth phase influence the transcriptome of Pseudomonas aeruginosa PAO1, identifying temperature- and phase-specific gene regulation and LasR-regulated genes at different temperatures.

The paper isolates PcrV-specific B cells from cystic fibrosis patients and generates monoclonal antibodies that reduce Pseudomonas aeruginosa burden in mice.

This study shows that serotype switching in Pseudomonas aeruginosa ST111 from O4 to O12 enhances adhesion, motility, and virulence in murine pneumonia.

The paper investigates how O-specific antigen loss in Pseudomonas aeruginosa affects population dynamics and aggregate formation in a murine infection model.

The paper characterizes the functional metabolic diversity of Pseudomonas aeruginosa clinical isolates by analyzing genotype-phenotype correlations and genome-scale metabolic networks.

This study shows that de novo mutations in Burkholderia dolosa cause phenotypic switching, with O-antigen loss increasing immune cell uptake but reducing lung competitiveness, depending on infection duration and tissue localization.

The paper analyzes the agr operon across S. aureus genomes to identify frameshift mutations and their evolutionary patterns, finding over 5% of strains have non-functional agr systems.

The paper shows that using microbiome data improves predictive models of lung function in cystic fibrosis patients, with non-pathogenic taxa also contributing to predictions.