Cdc42 small GTPase is a novel regulator of the fibrogenic activation of human intestinal myofibroblasts
Atif Zafar, Gaurav Chauhan, Pranab K. Mukherjee, Armando Marino‐Melendez, Ryan J. Musich, Y Wang, Nayden G. Naydenov, Florian Rieder, Andrei I. Ivanov
This study shows that Cdc42 regulates fibrogenic activation of human intestinal myofibroblasts by enhancing ECM production and contractile actomyosin cytoskeleton through AKT-mTOR signaling.
bioRxiv · Jul 10, 2026 · PreprintCell Biology