Andrei I. Ivanov

This study shows that SETD3 methylates actin, enhancing F-actin polymerization and protecting intestinal epithelial barrier integrity, and its loss worsens inflammation and permeability.

This study shows that Cdc42 regulates fibrogenic activation of human intestinal myofibroblasts by enhancing ECM production and contractile actomyosin cytoskeleton through AKT-mTOR signaling.

This study shows that NM IIA limits A/E bacterial colonization by inhibiting actin pedestal formation, while NM IIC does not play a similar role.

This study investigates the role of SEPT9 in intestinal epithelial barrier integrity and inflammation, finding that its loss disrupts tight junctions and increases susceptibility to colitis.

This study shows that intestinal stem cells (ISCs) enhance local mucosal immunity by engulfing apoptotic bodies, which leads to increased T cell activity through TNF signaling.