Ryan J. Musich

This study shows that Cdc42 regulates fibrogenic activation of human intestinal myofibroblasts by enhancing ECM production and contractile actomyosin cytoskeleton through AKT-mTOR signaling.

The paper identifies complement biomarkers in urine linked to alcohol-associated liver disease and provides insights into liver-kidney crosstalk mechanisms.

This study shows that NF-kB-dependent transcription of Piezo1 in macrophages enhances bacterial clearance during pneumonia by promoting lysosome biogenesis and stiffness-dependent phagolysosome maturation.

This study investigates the role of SEPT9 in intestinal epithelial barrier integrity and inflammation, finding that its loss disrupts tight junctions and increases susceptibility to colitis.

This study compares droplet-based and picowell-based single-cell RNA sequencing platforms for human colon biopsies, finding differences in cell recovery, typeability, and gene expression consistency.

This paper develops an in vitro model of the human intestinal epithelium that closely mimics in vivo cell types using single-cell transcriptomics and a biomedical foundation model.