BiochemistryMolecular MetabolismPeer-reviewed
Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells
Allison Grenell, Charandeep Singh, Monisha Raju…·Bela Anand‐Apte
This study shows that TIMP3 mutations in RPE cells increase glycolytic activity and disrupt glutamine metabolism, linking these changes to Sorsbys Fundus Dystrophy.