Genetic ablation of SOD1G37R selectively from corticofugal projection neurons protects corticospinal neurons from degeneration without affecting ALS onset and progression
Jelena Scekic‐Zahirovic, Mathieu Fischer, Geoffrey Stuart Lopez, Thibaut Burg, Marie‐Christine Birling, Pascal Kessler, Caroline Rouaux
The paper shows that removing mutant SOD1G37R from corticofugal projection neurons prevents their degeneration but does not affect ALS onset or progression.
bioRxiv · Jan 9, 2020 · PreprintNeuroscience