Author

Jelena Scekic‐Zahirovic

InsermORCID 0000-0002-4763-0179Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 4 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Caroline RouauxiD· 3 shared Mathieu FischeriD· 3 shared Thibaut BurgiD· 3 shared Pascal KessleriD· 2 shared Albert Christian LudolphiD· 1 shared Anne‐Laurence BoutillieriD· 1 shared Aurore BrunetiD· 1 shared Céline KeimeiD· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Caroline RouauxORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses

Jelena Scekic‐Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa W. Y. Kan, Salim Megat, Pierre De Rossi, Stéphane Dieterle, Raphaelle Cassel, Marguerite Jamet, Pascal Kessler, Diana Wiesner, Laura Tzeplaeff, Valérie Demais, Sonu Sahadevan, Katharina Hembach, Hans‐Peter Müller, , Luc Dupuis

This study shows that cytoplasmic FUS mislocalization in mice causes behavioral changes and inhibitory synaptic defects without widespread neuronal loss.

Nature Communications · May 21, 2021Peer-reviewedNeuroscience

Genetic ablation of SOD1G37R selectively from corticofugal projection neurons protects corticospinal neurons from degeneration without affecting ALS onset and progression

Jelena Scekic‐Zahirovic, Mathieu Fischer, Geoffrey Stuart Lopez, Thibaut Burg, Marie‐Christine Birling, Pascal Kessler, Caroline Rouaux

The paper shows that removing mutant SOD1G37R from corticofugal projection neurons prevents their degeneration but does not affect ALS onset or progression.

bioRxiv · Jan 9, 2020 · PreprintNeuroscience

Absence of subcerebral projection neurons delays disease onset and extends survival in a mouse model of ALS

Thibaut Burg, Charlotte Bichara, Jelena Scekic‐Zahirovic, Mathieu Fischer, Geoffrey Stuart‐Lopez, François Lefèbvre, Matilde Cordero‐Erausquin, Caroline Rouaux

This study shows that removing subcerebral projection neurons in ALS mice delays disease onset and improves survival, supporting the corticofugal hypothesis of ALS.

bioRxiv · Nov 21, 2019 · PreprintNeuroscience

Early alterations of RNA metabolism and splicing from adult corticospinal neurons in an ALS mouse model

Christine Marques, Mathieu Fischer, Céline Keime, Thibaut Burg, Aurore Brunet, Jelena Scekic‐Zahirovic, Caroline Rouaux

The paper identifies early RNA metabolism and splicing alterations in corticospinal neurons in an ALS mouse model, suggesting shared mechanisms across ALS-related genes.

bioRxiv · Jun 12, 2019 · PreprintNeuroscience