Thibaut Burg

This paper introduces human myelin spheres (MyS) as a model for studying myelination and demyelination, showing their ability to form myelinated neurons and mimic in vivo oligodendrocyte development.

This study identifies PP2A and GSK3 as modifiers of FUS-ALS by modulating mitochondrial transport in Drosophila and human iPSC-derived motor neurons.

The paper shows that removing mutant SOD1G37R from corticofugal projection neurons prevents their degeneration but does not affect ALS onset or progression.

This study shows that removing subcerebral projection neurons in ALS mice delays disease onset and improves survival, supporting the corticofugal hypothesis of ALS.

The paper identifies early RNA metabolism and splicing alterations in corticospinal neurons in an ALS mouse model, suggesting shared mechanisms across ALS-related genes.