Author

Pascal Kessler

InsermORCID 0000-0003-3323-3647Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1

Frequent Co-Authors

Albert Christian LudolphiD· 2 shared Caroline RouauxiD· 2 shared Jelena Scekic‐ZahiroviciD· 2 shared Luc DupuisiD· 2 shared Mathieu FischeriD· 2 shared Salim MegatiD· 2 shared Sylvie Dirrig‐Grosch· 2 shared Adriano ChiòiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenomics

Albert Christian LudolphORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintOct 10, 2024

CREB3 gain of function variants protect against ALS

Salim Megat, Christine Marques, Marina Hernán-Godoy…·Caroline Rouaux

The paper identifies a protective variant CREB3R119G that reduces ALS risk and progression by modulating CREB3 activity in vulnerable neurons.

1 citation

𝕏 PostBluesky

NeuroscienceNature CommunicationsPeer-reviewedMay 21, 2021

Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses

Jelena Scekic‐Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa W. Y. Kan…·Luc Dupuis

This study shows that cytoplasmic FUS mislocalization in mice causes behavioral changes and inhibitory synaptic defects without widespread neuronal loss.

66 citationstop 4%

mousestatistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintJan 9, 2020

Genetic ablation of SOD1G37R selectively from corticofugal projection neurons protects corticospinal neurons from degeneration without affecting ALS onset and progression

Jelena Scekic‐Zahirovic, Mathieu Fischer, Geoffrey Stuart Lopez…·Caroline Rouaux

The paper shows that removing mutant SOD1G37R from corticofugal projection neurons prevents their degeneration but does not affect ALS onset or progression.

2 citations

mouseexperimental assay

𝕏 PostBluesky