Direct evidence of acid-driven protein desolvation
Farzad Hamdi, Ioannis Skalidis, Inken Kaja Schwerin, Jaydeep Belapure, Dmitry A. Semchonok, Fotis L. Kyrilis, Christian Tüting, Johannes Müller, Georg Künze, Panagiotis L. Kastritis
The paper examines hydration changes in a protein complex across pH values using cryo-EM and simulations, showing significant water loss and its link to metal release.
Proceedings of the National Academy of Sciences · Mar 5, 2026Peer-reviewedBiochemistry