Panagiotis L. Kastritis

Structural basis for far-red light harvesting in a euglenophyte photosystem II supercomplex

The paper presents a cryo-EM structure of a euglenophyte PSII supercomplex and identifies LhcE9 as a far-red light-harvesting antenna subunit with unique structural and functional properties.

SNPstar: A Web Server Linking Allelic Variation to Protein Structure and Function in Arabidopsis thaliana

SNPstar links SNPs in Arabidopsis thaliana to protein structure and function using AlphaFold3 predictions, enabling variant characterization and geographic mapping.

Revisiting p53:Sirt1 interaction in the light of controlling p53 acetylation levels

This study presents the first structural model of the full-length p53:Sirt1 complex, showing Sirt1 selectively deacetylates p53 at K582 and binds acetylated p53 with a 1:1 stoichiometry.

A nested shell structure coordinates enzyme communication in pyruvate oxidation

This paper proposes a multi-scale model of the pyruvate dehydrogenase complex (PDHc) revealing a nested shell structure that coordinates enzyme communication during pyruvate oxidation.

A 37-million-particle dataset from over 250 experiments to accelerate data-driven cryo-EM analysis

The paper introduces a large annotated cryo-EM particle dataset and validates it through reconstruction and model training.

Direct evidence of acid-driven protein desolvation

The paper examines hydration changes in a protein complex across pH values using cryo-EM and simulations, showing significant water loss and its link to metal release.

Structural basis of Arf1-driven membrane tubulation

This study determines the structural basis of Arf1-driven membrane tubulation using cryo-EM, revealing how Arf1 forms curved tubules and accommodates cargo.

Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1

This study identifies how bis-Tyr-phosphorylated Gab1 activates SHP2 by binding both SH2 domains and inducing structural changes.

Strategies for Mitigating Radiation Damage and Improving Data Completeness in 3D Electron Diffraction of Protein Crystals

This paper introduces a method to reduce radiation damage and improve data completeness in 3D electron diffraction by using multi-position acquisition from multiple crystals.

Structural basis of neurofibromin tetramerization and dimer-tetramer equilibrium

This study identifies a tetramer structure of neurofibromin and describes a dynamic dimer-tetramer equilibrium with functional implications.

IQD2 recruits KLCR1 to the membrane-microtubule nexus to promote cytoskeletal mechano-responsiveness in leaf epidermis pavement cells

This study identifies IQD2 and KLCR1 as a module that promotes microtubule mechano-responsiveness in plant pavement cells by localizing to the plasma membrane-microtubule nexus.

Novel exotic alleles of EARLY FLOWERING 3 determine plant development in barley

The paper identifies novel exotic ELF3 alleles in barley and shows they affect plant development traits by altering protein structure and function.

Insights on cross-species transmission of SARS-CoV-2 from structural modeling

This study uses structural modeling to analyze ACE2 orthologs and their interactions with SARS-CoV-2 spike protein, identifying mutations that affect susceptibility and suggesting therapeutic applications.