Fotis L. Kyrilis

This paper proposes a multi-scale model of the pyruvate dehydrogenase complex (PDHc) revealing a nested shell structure that coordinates enzyme communication during pyruvate oxidation.

The paper introduces a large annotated cryo-EM particle dataset and validates it through reconstruction and model training.

The paper examines hydration changes in a protein complex across pH values using cryo-EM and simulations, showing significant water loss and its link to metal release.

This study identifies how bis-Tyr-phosphorylated Gab1 activates SHP2 by binding both SH2 domains and inducing structural changes.

This paper introduces a method to reduce radiation damage and improve data completeness in 3D electron diffraction by using multi-position acquisition from multiple crystals.