Farzad Hamdi

Structural basis for far-red light harvesting in a euglenophyte photosystem II supercomplex

The paper presents a cryo-EM structure of a euglenophyte PSII supercomplex and identifies LhcE9 as a far-red light-harvesting antenna subunit with unique structural and functional properties.

A nested shell structure coordinates enzyme communication in pyruvate oxidation

This paper proposes a multi-scale model of the pyruvate dehydrogenase complex (PDHc) revealing a nested shell structure that coordinates enzyme communication during pyruvate oxidation.

Direct evidence of acid-driven protein desolvation

The paper examines hydration changes in a protein complex across pH values using cryo-EM and simulations, showing significant water loss and its link to metal release.

Structural basis of Arf1-driven membrane tubulation

This study determines the structural basis of Arf1-driven membrane tubulation using cryo-EM, revealing how Arf1 forms curved tubules and accommodates cargo.

Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1

This study identifies how bis-Tyr-phosphorylated Gab1 activates SHP2 by binding both SH2 domains and inducing structural changes.

Strategies for Mitigating Radiation Damage and Improving Data Completeness in 3D Electron Diffraction of Protein Crystals

This paper introduces a method to reduce radiation damage and improve data completeness in 3D electron diffraction by using multi-position acquisition from multiple crystals.