Time- and cell-dependent atypia and cell death are caused by progressive deficiency in DNA replication
Alex Y. Lin, Georgia K. Thomas, Khai Chung Ang, Damian B. van Rossum, Victor A. Canfield, Keith C. Cheng
This study shows that a zebrafish DNA polymerase mutation leads to DNA damage, S phase arrest, and cell death over time, with effects varying by cell type and replication rate.
bioRxiv · Dec 31, 2020 · PreprintGenetics