Author

Alex Y. Lin

Pennsylvania State UniversityORCID 0000-0002-1653-4168Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:zebrafish· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Keith C. ChengiD· 2 shared Andrew L. SugarmaniD· 1 shared Carolyn R. ZainoiD· 1 shared Damian B. van RossumiD· 1 shared Daniel J. VanselowiD· 1 shared Georgia K. Thomas· 1 shared John C. Leichty· 1 shared Justin D. SilvermaniD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersSystems Biology

Keith C. ChengORCID

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2 papers

Recent·Most cited

Quantitative Geometric Modeling of Blood Cells from X-ray Histotomograms of Whole Zebrafish Larvae

Maksim A. Yakovlev, Ke Liang, Carolyn R. Zaino, Daniel J. Vanselow, Andrew L. Sugarman, Alex Y. Lin, Patrick J. La Rivière, Yuxi Zheng, Justin D. Silverman, John C. Leichty, Xiaolei Huang, Keith C. Cheng

The paper develops a semi-automated method to segment and model blood cells in zebrafish larvae using X-ray histotomography, enabling quantitative geometric analysis across developmental stages and mutants.

bioRxiv · May 23, 2023 · PreprintSystems Biology

Time- and cell-dependent atypia and cell death are caused by progressive deficiency in DNA replication

Alex Y. Lin, Georgia K. Thomas, Khai Chung Ang, Damian B. van Rossum, Victor A. Canfield, Keith C. Cheng

This study shows that a zebrafish DNA polymerase mutation leads to DNA damage, S phase arrest, and cell death over time, with effects varying by cell type and replication rate.

bioRxiv · Dec 31, 2020 · PreprintGenetics