Vascular Progenitors Generated from Tankyrase Inhibitor-Regulated Naive Diabetic Induced Pluripotent Stem Cells Potentiate Efficient Revascularization of Ischemic Retina
Tea Soon Park, Ludovic Zimmerlin, Rebecca Evans-Moses, Justin Thomas, Jeffrey S. Huo, Riya Kanherkar, Alice He, Nensi Melissa Ruzgar, Rhonda R. Grebe, Imran Ahmed Bhutto, Michael I. Barbato, Michael A. Koldobskiy, Gerard A. Lutty, Elias T. Zambidis
This paper shows that reprogramming diabetic fibroblasts into naive hiPSC using tankyrase inhibitors improves vascular progenitor generation and revascularization in ischemic retinas.
Nature Communications · Mar 5, 2020Peer-reviewedDevelopmental Biology