CAIX-targeted α therapy directed against hypoxic tumor cells in combination with immune checkpoint inhibitors in a syngeneic mouse tumor model
Sylvia T.M. Wenker, Mark Konijnenberg, Daphne Lobeek, Giulia Tamborino, Janneke D.M. Molkenboer‐Kuenen, Gerben M. Franssen, Daan F. Boreel, Simone Caroline Kleinendorst, Hans Peters, Johan Bussink, Sanne A. M. van Lith, Sandra Heskamp
This study evaluates CAIX-targeted alpha therapy (TAT) alone and in combination with immune checkpoint inhibitors (ICI) in a syngeneic mouse tumor model, showing improved survival and tumor growth inhibition.
Theranostics · Feb 11, 2026Peer-reviewedCancer Biology