Johan Bussink

This study evaluates CAIX-targeted alpha therapy (TAT) alone and in combination with immune checkpoint inhibitors (ICI) in a syngeneic mouse tumor model, showing improved survival and tumor growth inhibition.

This study compares three nuclear imaging methods to quantify CD8+ T-cell infiltration in tumors, finding that two methods correlate with CD8+ T-cell counts while showing different distribution patterns.

This study investigates the combination of targeted radionuclide therapy and immune checkpoint inhibitors for advanced clear cell renal cell carcinoma, showing enhanced therapeutic outcomes and immune microenvironment changes.

This study identifies an adhesion-signalling mediated cell-state in HNSCC that drives drug tolerance, with a predictive transcriptional signature and functional validation.