Adaptation of α-synuclein fibrils following multiple system atrophy transmission to mice
Mylan Mayer, Chase R. Khedmatgozar, Gianna Zinnen, Matthew P. Frost, Patrícia Reis, Sara A. M. Holec, Melissa Dexter, Arthur A Melo, Eric Tse, Gregory E. Merz, Amanda L. Woerman
This study reports atomic resolution cryo-EM structures of α-synuclein fibrils from an MSA patient before and after transmission to a transgenic mouse model, showing structural adaptations while maintaining key features.
bioRxiv · May 12, 2026 · PreprintNeuroscience