Matthew P. Frost

This study reports atomic resolution cryo-EM structures of α-synuclein fibrils from an MSA patient before and after transmission to a transgenic mouse model, showing structural adaptations while maintaining key features.

The paper introduces a dual inducer system for RNAi complementation in Trypanosoma brucei, enabling independent and tunable regulation of gene expression to study kDNA replication.

The paper identifies key residues in α-synuclein that support misfolding in multiple system atrophy using mutagenesis and computational modeling.

The paper shows that cell-passaged tau fibrils from CBD and PSP patients generate heterogeneous fibrils with a subpopulation resembling the original disease fold.

The paper identifies Rbpms+ and Spp1+ microglia/macrophages in scRNA-seq data that mimic RGC markers, confounding RGC identification and proposes solutions to address this issue.