Sara A. M. Holec

This study reports atomic resolution cryo-EM structures of α-synuclein fibrils from an MSA patient before and after transmission to a transgenic mouse model, showing structural adaptations while maintaining key features.

This study investigates co-infection with two α-synuclein strains in mice, finding synergistic interactions that accelerate disease progression.

The paper identifies key residues in α-synuclein that support misfolding in multiple system atrophy using mutagenesis and computational modeling.