In silico, biochemical, and in vitro analysis of silvestrol binding to the DEAD box RNA helicase eIF4A reveals broad anti-pathogen potential of rocaglates across the eukaryotic tree of life
Wiebke Obermann, Mohammad Farhan Darin Azri, Leonie Konopka, Nina Schmidt, F. Magari, Julian Sherman, Liliana M. R. Silva, Carlos Rodrigo Hermosilla, Andreas H. Ludewig, Hicham Houhou, Simone Haeberlein, Mona Yiting Luo, Irina Häcker, Marc F. Schetelig, Christoph Gero Grevelding, , Gaspar Taroncher‐Oldenburg
The paper analyzes eIF4A sequence variants across eukaryotes to assess rocaglate sensitivity, revealing broad anti-pathogen potential and resistance patterns.
bioRxiv · Sep 9, 2022 · PreprintMolecular Biology