The RNA helicase eIF4A as a novel target in insect cells to combat arboviral infections
Tanja Rehling, Kim Mentchen, Leonie Konopka, Wiebke Obermann, Friedemann Weber, Patrick Schmerer, Marc F. Schetelig, Arnold Grünweller, Irina Häecker, F. Magari
This paper identifies eIF4A as a druggable host factor in insect vectors that can be targeted by rocaglates and pateamines to suppress arboviral replication.
PLoS ONE · Apr 6, 2026Peer-reviewedMolecular Biology