Simone Haeberlein

G protein-coupled receptor SmGPCR9 interacts with neuropeptides and controls spermatogenesis in Schistosoma mansoni

This study identifies SmGPCR9 as a GPCR involved in spermatogenesis and reproductive biology in Schistosoma mansoni, showing interactions with neuropeptides and functional effects through RNAi.

Host-specific platelet-activating factor acetylhydrolase selectively remodels diacylglycerophospholipids to control schistosome development

This study identifies host-derived PAFAH as a schistosomicidal phospholipase that remodels diacylglycerophospholipids, impairing schistosome development and survival.

Single-cell transcriptomics identifies a p21-activated kinase important for survival of the zoonotic parasite Fasciola hepatica

The paper uses scRNA-seq to analyze Fasciola hepatica cells, identifies new cell types and gene expression patterns, and highlights PAK4's role in parasite survival.

Spatial transcriptomics of a parasitic flatworm provides a molecular map of vaccine candidates, drug targets and drug resistance genes

The paper presents the first spatial transcriptome of the liver fluke Fasciola hepatica, identifying gene expression profiles and markers for eight tissues, with focus on vaccine candidates, drug targets, and resistance genes.

In silico, biochemical, and in vitro analysis of silvestrol binding to the DEAD box RNA helicase eIF4A reveals broad anti-pathogen potential of rocaglates across the eukaryotic tree of life

The paper analyzes eIF4A sequence variants across eukaryotes to assess rocaglate sensitivity, revealing broad anti-pathogen potential and resistance patterns.