In silico, biochemical, and in vitro analysis of silvestrol binding to the DEAD box RNA helicase eIF4A reveals broad anti-pathogen potential of rocaglates across the eukaryotic tree of life
Wiebke Obermann, Mohammad Farhan Darin Azri, Leonie Konopka…·Gaspar Taroncher‐Oldenburg
The paper analyzes eIF4A sequence variants across eukaryotes to assess rocaglate sensitivity, revealing broad anti-pathogen potential and resistance patterns.