Human 3D epithelioids enable continuous long-term clonal evolution studies across multiple epithelial tissues
Inês Ferreira, Alberto Pradilla-Dieste, Jose Antonio Valverde-Lopez, Federico Abascal, Yoshihiro Ishida, Marta Baselga, Moritz Jakob Przybilla, Andrew R. J. Lawson, Pantelis A. Nicola, Adrian Baez‐Ortega, Richard Butler, Mario Soriano‐Navarro, Michelle Miniter, Kasandra Malasi, Carmen Sancho‐Serra, , David Fernández‐Antorán
This study develops human epithelioids as a 3D culture system that maintains architecture, heterogeneity, and clonal evolution over time, enabling long-term studies of tissue dynamics and therapeutic responses.
bioRxiv · Jun 8, 2026 · PreprintCancer Biology