Carmen Sancho‐Serra

Full-thickness spatial transcriptomics of the human uterus reveals basalis niche architecture and regeneration gradients during menstrual breakdown

This study uses spatial transcriptomics to map gene expression gradients in the human endometrium, revealing coordinated regeneration and niche architecture during menstrual breakdown.

An integrated multimodal pan-organ atlas of the female reproductive system across the lifespan contextualises gynaecological pathologies

This paper creates an integrated multimodal atlas of the female reproductive system across the lifespan, identifying cell types and linking them to gynaecological pathologies.

Human 3D epithelioids enable continuous long-term clonal evolution studies across multiple epithelial tissues

This study develops human epithelioids as a 3D culture system that maintains architecture, heterogeneity, and clonal evolution over time, enabling long-term studies of tissue dynamics and therapeutic responses.

Spatial atlas of the ovary identifies molecular events in primordial follicle activation in humans

This study creates a comprehensive spatial atlas of the human ovarian cortex, revealing molecular mechanisms of primordial follicle activation and follicle niche organization.

Decoding human B cell ontogeny in prenatal and adult bone marrow and in vitro models via single-cell multiomics

This study creates a single-cell multiomics atlas of B cell development in prenatal and adult bone marrow and in vitro models, identifying novel cell subsets and molecular signatures.

Spatiotemporal map of the developing human reproductive tract at single-cell resolution

This study creates a single-cell spatial atlas of the developing human reproductive tract, identifying genes and mechanisms involved in sexual dimorphism and organ development.

An integrated single-cell reference atlas of the human endometrium

The paper constructs a high-resolution single-cell reference atlas of the human endometrium, identifying cell types, states, and signaling networks, and links them to endometriosis.

A developmental cell atlas of the human thyroid gland

This study creates a developmental cell atlas of the human thyroid gland using single-cell sequencing, revealing cell type heterogeneity and its implications in thyroid disorders and cancer.

Early infection response of the first trimester human placenta at single-cell scale

This study uses single-cell transcriptomics to map the early placental response to three pathogens in first-trimester human placenta, identifying coordinated inflammatory responses and pathogen-specific effects.

Successful placentation in human pregnancy is regulated by reciprocal interactions between maternal uterine NK cells and fetal placental trophoblast

The paper identifies a uNK-derived cytokine signal that promotes trophoblast differentiation and influences placental function and pregnancy outcomes.

Robust temporal map of human in vitro myelopoiesis using single-cell genomics

The paper generates a molecular map of human in vitro myelopoiesis from iPSC to macrophages, revealing conserved regulatory networks and new myeloid progenitors.

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

This study maps the temporal and spatial dynamics of the human endometrium using single-cell and spatial reference maps, identifying key signaling pathways regulating cell fate in vivo and in vitro.