Richard Butler

Tissue-wide metabolic buffering confers resilience to mitochondrial dysfunction

The paper shows that tissue-wide metabolic buffering allows neural stem cells to maintain proliferation despite mitochondrial dysfunction, highlighting the role of tissue heterogeneity in resilience.

Combinatorial screening of biological degrader modules identifies heterobifunctional molecules that efficiently destroy MYC, leading to rapid tumour cell death in vitro and in vivo

Human 3D epithelioids enable continuous long-term clonal evolution studies across multiple epithelial tissues

This study develops human epithelioids as a 3D culture system that maintains architecture, heterogeneity, and clonal evolution over time, enabling long-term studies of tissue dynamics and therapeutic responses.

A lineage-resolved multimodal single-cell atlas reveals the genomic dynamics of early C. elegans development

This study constructs a lineage-resolved single-cell multimodal atlas of early C. elegans development, revealing genomic dynamics and zygotic genome activation mechanisms.

The open to closed D-loop conformational switch determines length in filopodia-like actin bundles

The paper identifies antibodies that lengthen filopodia-like actin bundles by stabilizing the open D-loop conformation of actin filaments, revealing a mechanism for regulating their length.

Targeting the acetyltransferase NAT10 corrects pathologies in human frontotemporal dementia neurons and extends lifespan in an in vivo Drosophila tauopathy model

The paper shows that inhibiting NAT10 corrects nuclear defects and extends lifespan in tauopathy models.

RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells