Mario Soriano‐Navarro

Quantitative spatial connectomics of liver reveals a partially exposed sympathetic network that integrates multiple cell types across the portal tract

The paper uses EM-based spatial connectomics to reveal the 3D structure of the mouse liver's sympathetic network, showing it is a meshwork with exposed varicosities and diverse cellular contacts.

Human 3D epithelioids enable continuous long-term clonal evolution studies across multiple epithelial tissues

This study develops human epithelioids as a 3D culture system that maintains architecture, heterogeneity, and clonal evolution over time, enabling long-term studies of tissue dynamics and therapeutic responses.

Plastin-3 membrane recruitment drives cell-in-cell invasion during entosis

This study identifies Plastin-3 membrane recruitment as a critical step driven by ROCK1 activation in the entosis process.

Preferential vulnerability of cortical GABAergic interneurons to Nalcn deficiency

This study shows that NALCN deficiency preferentially affects GABAergic interneurons, reducing their intrinsic excitability and impairing contextual adaptation and spatial memory in mice.

Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells.

This study identifies how different GSDMB isoforms and protease cleavage regulate pyroptosis and mitochondrial damage in cancer cells.