An ER Retrieval-and-Release System Reveals Ligand-Independent Basal Signaling by Cell Surface TCRs
Claudia Juraske, Simon Beyer, Sara Hartmann, Daniel Peschkov, Emmanuelle Moraes Ribeiro, Hamidreza Ebrahimiyan, Katharina Ruoff, Felix Rainer Schmid, Anna Morath, Manuel Dorer, Friedel Drepper, Balbino Alarcón, Gina Fiala, Mohsen Basiri, Bjoern Lillemeier, , Wolfgang Schamel
The paper develops an ER retrieval-and-release system to study ligand-independent basal TCR signaling, finding that surface TCRs generate distinct phosphorylation patterns compared to ligand-induced activation.
bioRxiv · Oct 14, 2026 · PreprintImmunology